A 30-Day Preclinical Safety Evaluation Study of Recombinant Human Follicle-Stimulating Hormone in Female Rhesus Monkeys
نویسندگان
چکیده
منابع مشابه
P-101: Advantages of Recombinant Follicle- Stimulating Hormone over Human Menopausal Gonadotropin for Ovarian Stimulation in Intrauterine Insemination: A Randomized Clinical Trial in Unexplained Infertility
Background To compare two different gonadotropin preparations, human menopausal gonadotropin (hMG) and recombinant follicle-stimulating hormone (rFSH), combined with clomiphene citrate (CC) in women with unexplained infertility undergoing intrauterine insemination (IUI). MaterialsAndMethods In this prospective clinical trial, couples prepared for IUI cycles were randomly allocated to two groups...
متن کاملComparison of daily and alternate day recombinant follicle-stimulating hormone stimulation protocols for intrauterine insemination.
OBJECTIVE To determine the efficacy of daily versus alternate-day stimulation for patients undergoing intrauterine insemination (IUI). DESIGN Retrospective comparative study. SETTING University tertiary care center for infertility. PATIENT(S) Women with anovulatory or unexplained infertility for over 12 months who had not responded to or not conceived with clomiphene citrate treatment. ...
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Hematide is a synthetic peptide-based, pegylated erythropoiesis stimulating agent in clinical development for treatment of anemia. To support chronic clinical dosing requirements, a 9-month repeat dose IV monkey safety study was undertaken. Animals received 0, 0.2, 2 or 20 mg/kg hematide IV every three weeks for nine months followed by a 14-week recovery. Hematide administration was associated ...
متن کاملOvernight radioimmunoassay of human follicle-stimulating hormone.
A radioimmunoassay procedure for follicle-stimulating hormone in serum has been developed in which the assay mixture is incubated at 37#{176}C for a total of 22 h, rather than at 4#{176}C for 4-7 days. The withinassay coefficients of variation for the 37#{176}C and 4#{176}C methods, respectively, are 7.7% and 5.0%, while the between-assay variations are 13.8% and 9.9%. Comparison of values for ...
متن کاملFollicle-stimulating hormone increases bone mass in female mice.
Elevated follicle-stimulating hormone (FSH) activity is proposed to directly cause bone loss independent of estradiol deficiency in aging women. Using transgenic female mice expressing human FSH (TgFSH), we now reveal that TgFSH dose-dependently increased bone mass, markedly elevating tibial and vertebral trabecular bone volume. Furthermore, TgFSH stimulated a striking accrual of bone mass in h...
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ژورنال
عنوان ژورنال: International Journal of Toxicology
سال: 2011
ISSN: 1091-5818,1092-874X
DOI: 10.1177/1091581810390823